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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCA2 All Species: 8.18
Human Site: T1618 Identified Species: 15
UniProt: Q9BZC7 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BZC7 NP_001597 2435 269873 T1618 W N V S L P P T A G P E M W T
Chimpanzee Pan troglodytes XP_001152577 2346 264166 P1541 W K T P S V S P N I T Q L F Q
Rhesus Macaque Macaca mulatta XP_001117819 2476 273629 T1645 W N V S L P P T A G P E M W T
Dog Lupus familis XP_537788 2395 264756 S1591 S E Y L L F T S D R F R L H R
Cat Felis silvestris
Mouse Mus musculus P41234 2434 270490 P1618 A W N M S L P P T A G P E T W
Rat Rattus norvegicus Q9ESR9 2434 270910 P1618 A W N T S L P P T A G P E T W
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516009 2266 254238 T1498 P P Q R K Q H T A D I L Q N L
Chicken Gallus gallus XP_422330 2276 256293 V1508 G L P P P Q R V Q H S T E I L
Frog Xenopus laevis NP_001089022 2363 267334 S1566 T R D N P S P S C T C S T R S
Zebra Danio Brachydanio rerio NP_001139161 2268 254351 H1500 P P Q I K V T H D E T L Q N L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34358 1704 191394 S936 Q A R G P E K S G V A K M V A
Sea Urchin Strong. purpuratus XP_798273 1913 213253 E1145 Y P S S S P A E M E N D E T E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84M24 1882 209045 D1113 L M D G Q H P D G S L G Y T V
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 35.1 96 82.2 N.A. 91 92.9 N.A. 39.1 35.7 36.5 37.7 N.A. N.A. N.A. 23.7 41.7
Protein Similarity: 100 52 96.6 86.1 N.A. 93.2 94.9 N.A. 55.7 53.5 54.7 54.5 N.A. N.A. N.A. 39 54.4
P-Site Identity: 100 6.6 100 6.6 N.A. 6.6 6.6 N.A. 13.3 0 6.6 0 N.A. N.A. N.A. 6.6 13.3
P-Site Similarity: 100 26.6 100 20 N.A. 6.6 13.3 N.A. 13.3 0 26.6 0 N.A. N.A. N.A. 20 26.6
Percent
Protein Identity: N.A. N.A. N.A. 26.2 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 42.6 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 8 0 0 0 0 8 0 24 16 8 0 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 8 0 8 0 0 0 0 % C
% Asp: 0 0 16 0 0 0 0 8 16 8 0 8 0 0 0 % D
% Glu: 0 8 0 0 0 8 0 8 0 16 0 16 31 0 8 % E
% Phe: 0 0 0 0 0 8 0 0 0 0 8 0 0 8 0 % F
% Gly: 8 0 0 16 0 0 0 0 16 16 16 8 0 0 0 % G
% His: 0 0 0 0 0 8 8 8 0 8 0 0 0 8 0 % H
% Ile: 0 0 0 8 0 0 0 0 0 8 8 0 0 8 0 % I
% Lys: 0 8 0 0 16 0 8 0 0 0 0 8 0 0 0 % K
% Leu: 8 8 0 8 24 16 0 0 0 0 8 16 16 0 24 % L
% Met: 0 8 0 8 0 0 0 0 8 0 0 0 24 0 0 % M
% Asn: 0 16 16 8 0 0 0 0 8 0 8 0 0 16 0 % N
% Pro: 16 24 8 16 24 24 47 24 0 0 16 16 0 0 0 % P
% Gln: 8 0 16 0 8 16 0 0 8 0 0 8 16 0 8 % Q
% Arg: 0 8 8 8 0 0 8 0 0 8 0 8 0 8 8 % R
% Ser: 8 0 8 24 31 8 8 24 0 8 8 8 0 0 8 % S
% Thr: 8 0 8 8 0 0 16 24 16 8 16 8 8 31 16 % T
% Val: 0 0 16 0 0 16 0 8 0 8 0 0 0 8 8 % V
% Trp: 24 16 0 0 0 0 0 0 0 0 0 0 0 16 16 % W
% Tyr: 8 0 8 0 0 0 0 0 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _